There is no single “murder defense” or “assault defense.” The strategy depends on what the State must prove and where the evidence breaks.
Identity
Does reliable evidence actually place the accused as the person who committed the charged act? Video, phones, eyewitness identification, DNA, fingerprints, and timelines may point in different directions.
Forensic evidence
Firearms, residue, autopsy findings, medical records, DNA, digital evidence, and laboratory conclusions should be tested against the underlying methodology and chain of custody.
Self-defense
The question may be whether force was legally justified, including what threat existed, who initiated or escalated the confrontation, and what the accused reasonably perceived at the time.
Mental state
Murder, manslaughter, and criminally negligent homicide require different culpable mental states. What the State can prove about intent, knowledge, recklessness, or negligence can change the offense itself.
Witness credibility
Inconsistent statements, bias, motive, plea agreements, benefits, intoxication, perception, and prior contradictory accounts can materially change how a jury evaluates a witness.
Constitutional issues
Statements, searches, warrants, seizures, identification procedures, and other evidence may require litigation before trial. Suppression can reshape the case the jury ultimately sees.